Alhambra, winner of the Spiel des Jahres 2003, is considered by some to be one of the "Big Three" German style family games that propelled Eurogames to the forefront of hobby gaming. The other two being Settlers of Catan and Carcassone.
We can quibble over whether or not Alhambra deserves to be included among the "Big Three," the extent of its influence, and its role in the trend of naming games for places. However, we cannot deny that at one point in time it was a game that every hobby gamer knew. It was one of the go-to games that you could slap down on a table and just start playing, because everyone had played and knew the rules.
Although Alhambra has remained in print for over a decade and spawned 6 expansions, as well as the Alhambra Card Game, it seems to have faded in popularity. Where once the answer to the question, "What games introduced you to hobby gaming?" typically included Alhambra, now the answer is more likely to include Dominion or Pandemic.